解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Perioperative complications occur in 30-40% of non-cardiac surgical patients and are the leading cause of early postoperative morbidity and mortality. Regular visits by trained health professionals may decrease the incidence of complications and mortality through earlier detection and adequate treatment of c...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2952-5
更新日期:2018-10-26 00:00:00
abstract:BACKGROUND:Patient-reported outcomes measures in clinical trials ensure that evaluations of effectiveness focus on outcomes that are important to patients. In relapsing-remitting conditions, such as eczema, repeated measurements may allow a more accurate reflection of disease burden and treatment effect than less frequ...
journal_title:Trials
pub_type: 杂志文章,多中心研究
doi:10.1186/s13063-018-2962-3
更新日期:2018-10-24 00:00:00
abstract:BACKGROUND:Acupuncture has been widely applied in the clinic to treat irritable bowel syndrome (IBS), but the underlying mechanism remains unknown. Diffuse noxious inhibitory control (DNIC) is deficient in patients with IBS, which attenuates the systemic analgesic effect elicited by noxious stimulation that is remote f...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2948-1
更新日期:2018-10-16 00:00:00
abstract:BACKGROUND:In bipolar spectrum disorder, some individuals experience ongoing, frequent fluctuations in mood outside of affective episodes. There are currently no evidence-based psychological interventions designed to address this. This feasibility study is a phase II evaluation of a dialectical behavioural therapy-info...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2926-7
更新日期:2018-10-16 00:00:00
abstract:BACKGROUND:Endoscopic ultrasonography (EUS)-guided drainage has become the first-line therapy for late peri-pancreatic fluid collection (PFC). Double pigtail plastic stents (DPPS) and lumen-apposing metal stents (LAMS) are commonly used for PFC drainage. Recently, a multi-institutional consensus on PFC drainage has rec...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2901-3
更新日期:2018-10-11 00:00:00
abstract:BACKGROUND:An increasing number of clinical trials of traditional Chinese medicine are being conducted in the treatment of non-valvular atrial fibrillation (NVAF) in China. However, the heterogeneity of outcomes and outcome measurement instruments has produced little evidence for traditional Chinese medicine in treatin...
journal_title:Trials
pub_type: 共识发展会议,杂志文章
doi:10.1186/s13063-018-2904-0
更新日期:2018-10-05 00:00:00
abstract:BACKGROUND:There are more than a quarter of a million individuals aged ≥ 65 years who are resident in care homes in England and Wales. Care home residents have high levels of cognitive impairment, physical disability, multimorbidity and polypharmacy. Research is needed to ensure there are robust, evidence-based interve...
journal_title:Trials
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s13063-018-2915-x
更新日期:2018-10-03 00:00:00
abstract:BACKGROUND:Clinical cancer trials are crucial for the implementation of new treatments in the clinical setting, but it is equally crucial that patients are given the opportunity to make a well-informed decision about participation. The inclusion process is complex, including both oral and written information about the ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2916-9
更新日期:2018-09-29 00:00:00
abstract:BACKGROUND:Generalised anxiety disorder (GAD) is a chronic and debilitating condition characterised by high co-morbidity. Alongside pharmacological treatment, cognitive behavioural therapy (CBT) is an established psychological therapy for GAD. Its effectiveness is limited, however, with only an estimated 50% of clients...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2892-0
更新日期:2018-09-19 00:00:00
abstract:BACKGROUND:Written participant information materials are important for ensuring that potential trial participants receive necessary information so that they can provide informed consent. However, such materials are frequently long and complex, which may negatively impact patient understanding and willingness to partici...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-018-2896-9
更新日期:2018-09-18 00:00:00
abstract:BACKGROUND:Hospitalized older persons with Alzheimer's disease and related dementias are at greater risk for functional decline and increased care dependency after discharge due to a combination of intrinsic factors, environmental, policy, and care practices that restrict physical and cognitive activity, lack of family...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2875-1
更新日期:2018-09-17 00:00:00
abstract:BACKGROUND:There is a strong evidence base for the benefits of parenting interventions for parents without severe mental illness (SMI). As the impact of maternal SMI can be significant on child development, mothers need support to maximise outcomes for themselves and their children. Some mothers with SMI require admiss...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2869-z
更新日期:2018-09-10 00:00:00
abstract:BACKGROUND:Adolescent idiopathic scoliosis (AIS) is one of the most prevalent spinal deformities that may progress sharply during growth. The aim of this study will be to evaluate the efficacy of three-dimensionally integrated exercise on the Cobb angle, angle of trunk rotation, sagittal profile, and quality of life in...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2834-x
更新日期:2018-09-10 00:00:00
abstract:BACKGROUND:Palmoplantar pustulosis is a rare but painful and debilitating disease. It consistently ranks the highest of all psoriasis phenotypic variants in terms of symptoms and functional impairment. Management of plaque-type psoriasis has been revolutionised in the last 10 years with the advent of biologic therapies...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2841-y
更新日期:2018-08-29 00:00:00
abstract:BACKGROUND:Nitrogen containing bisphosphonates such as zoledronic acid (ZA) are known to contain certain anti-cancer properties. These have been investigated in the past in various cancers such as breast, prostate and colon. ZA in particular has shown promising results in pre-clinical studies. We propose a multicentre ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2851-9
更新日期:2018-08-29 00:00:00
abstract:BACKGROUND:Older adults living in nursing homes spend the majority of their time inactive. The associated levels of chronic disease place an increasing burden on healthcare systems. Physical activity (PA) interventions delivered through exercise classes may be resource-intensive and require specialist staff. The aim of...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2848-4
更新日期:2018-08-29 00:00:00
abstract:BACKGROUND:There has been a recent steep growth in platelet-rich plasma (PRP) use for musculoskeletal conditions, but findings from high quality clinical trial data are lacking in the literature. Here, we describe the statistical analysis plan (SAP) for the Platelet-rich plasma in Achilles Tendon Healing 2 (PATH-2) tri...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2840-z
更新日期:2018-08-29 00:00:00
abstract:BACKGROUND:Registration of clinical trials is critical for promoting transparency and integrity in medical research; however, trials must be registered in a prospective fashion to deter unaccounted protocol modifications or selection of alternate outcomes that may enhance favorability of reported findings. We assessed ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2825-y
更新日期:2018-08-23 00:00:00
abstract:BACKGROUND:There are marked disparities between pre-school children in key skills affecting school readiness, disparities that commonly persist and influence children's later academic achievements, employment, and adjustment. Much of this disparity is linked to socio-economic disadvantage and its impact on the home lea...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-018-2700-x
更新日期:2018-08-22 00:00:00
abstract:BACKGROUND:Osteoarthritis often results in prolonged periods of reduced physical activity and is associated with adverse health outcomes, including increased risk of cardiovascular and metabolic diseases. Exercise interventions for patients on the waiting list for arthroplasty can reduce the risk of long-term adverse o...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2808-z
更新日期:2018-08-07 00:00:00
abstract:BACKGROUND:Young men in South Africa face concurrent epidemics of HIV, drug and alcohol abuse, and unemployment. Standard HIV prevention programs, located in healthcare settings and/or using counseling models, fail to engage men. Soccer and vocational training are examined as contexts to deliver male-specific, HIV prev...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2804-3
更新日期:2018-08-03 00:00:00
abstract:BACKGROUND:Dietary interventions have limited success in promoting sustainable weight loss; new treatments allowing better compliance with hypocaloric diets should be developed. The aim of this trial is to describe the effects of a protocol combining repetitive active transcranial direct current stimulation (tDCS) with...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2776-3
更新日期:2018-07-16 00:00:00
abstract:BACKGROUND:Conventional whole brain radiotherapy (WBRT) has been established as the treatment standard in patients with cerebral metastases from small-cell lung cancer (SCLC), however, it has only modest efficacy and limited prospective data is available for WBRT as well as local treatments such as stereotactic radiosu...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2745-x
更新日期:2018-07-16 00:00:00
abstract:BACKGROUND:Hand-assisted laparoscopic living donor nephrectomy (HALDN) using a periumbilical or Pfannenstiel incision was developed to improve donor outcome after a kidney transplant. The aim of this study was to investigate two methods of hand assistance and kidney removal during HALDN and their effect on the time it ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2775-4
更新日期:2018-07-13 00:00:00
abstract:BACKGROUND:Colorectal cancer remains a considerable challenge in healthcare nowadays. Most patients' disease develops via the adenoma-carcinoma sequence; colonoscopy with polypectomy effectively reduces both mortality and incidence by removing precancerous adenomas. Previous studies showed that polypectomy without elec...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2743-z
更新日期:2018-07-06 00:00:00
abstract:BACKGROUND:Using next-generation sequencing (NGS) in newborn screening (NBS) could expand the number of genetic conditions detected pre-symptomatically, simultaneously challenging current precedents, raising ethical concerns, and extending the role of parental decision-making in NBS. The NC NEXUS (Newborn Exome Sequenc...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2686-4
更新日期:2018-06-28 00:00:00
abstract:BACKGROUND:The preliminary results of a randomised controlled trial are presented. The aim of the trial is to determine the efficacy, feasibility and acceptability of email-delivered psychological interventions with telephone support, for adults injured in a motor vehicle crash engaged in seeking compensation. The prim...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-018-2716-2
更新日期:2018-06-27 00:00:00
abstract:BACKGROUND:Quality and service improvement (QSI) research employs a broad range of methods to enhance the efficiency of healthcare delivery. QSI research differs from traditional healthcare research and poses unique ethical questions. Since QSI research aims to generate knowledge to enhance quality improvement efforts,...
journal_title:Trials
pub_type: 信件
doi:10.1186/s13063-018-2724-2
更新日期:2018-06-25 00:00:00
abstract:BACKGROUND:The increasing prevalence of Alzheimer's disease and other forms of dementia raises new challenges to ensure that healthcare decisions are informed by research evidence and reflect what is important for seniors and their caregivers. Therefore, we aim to evaluate a tailored intervention to help healthcare pro...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2697-1
更新日期:2018-06-25 00:00:00
abstract:BACKGROUND:Patients can struggle to make sense of trials in emergency situations. This study examines patient experience of participating in the United Kingdom, Wound management of Open Lower Limb Fractures (UK WOLLF) study, a trial of standard wound management versus Negative Pressure Wound Therapy (NPWT). METHODS:Th...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-018-2722-4
更新日期:2018-06-25 00:00:00
abstract:BACKGROUND:Upper limb dysfunction is common after stroke, posing an important challenge for post-stroke rehabilitation. The clinical efficacy of acupuncture for the recovery of post-stroke upper limb function has been previously demonstrated. Mirror therapy (MT) has also been found to be effective. However, the effects...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2585-8
更新日期:2018-05-31 00:00:00
abstract:BACKGROUND:The current randomized controlled trial seeks to evaluate whether providing access to an Internet intervention for problem drinking in addition to an Internet intervention for problem gambling is beneficial for participants with gambling problems who do or do not have co-occurring problem drinking. METHODS:...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2672-x
更新日期:2018-05-25 00:00:00
abstract:BACKGROUND:The cross-sectional area of the subclavian vein (csSCV) is an important factor determining the success rate of SCV catheterization. The head-down position increases the csSCV. However, the effects of lateral tilting on subclavian venous cross-sectional area have not yet been explored. In this trial, we test ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2666-8
更新日期:2018-05-24 00:00:00
abstract:BACKGROUND:Sharing interim results by the Data Safety Monitoring Board (DSMB) with non-DSMB members is an issue that can affect trial integrity. It is unclear what should be shared. This study assesses the views of professionals to understand what interim information should be shared at interim, with whom and why. MET...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2655-y
更新日期:2018-05-21 00:00:00
abstract:BACKGROUND:Trials in rare diseases have many challenges, among which are the need to set up multiple sites in different countries to achieve recruitment targets and the divergent landscape of clinical trial regulations in those countries. Over the past years, there have been initiatives to facilitate the process of int...
journal_title:Trials
pub_type: 杂志文章,评审
doi:10.1186/s13063-018-2645-0
更新日期:2018-05-10 00:00:00
abstract:BACKGROUND:Post-stroke depression (PSD) is the most common psychiatric complication after a stroke. The most frequently used antidepressants are selective serotonin receptor inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), however, these exhibit a series of side effects. Traditional Chin...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2633-4
更新日期:2018-05-10 00:00:00
abstract:BACKGROUND:Evidence for benefit of high positive end-expiratory pressure (PEEP) is largely lacking for invasively ventilated, critically ill patients with uninjured lungs. We hypothesize that ventilation with low PEEP is noninferior to ventilation with high PEEP with regard to the number of ventilator-free days and bei...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2640-5
更新日期:2018-05-09 00:00:00
abstract:BACKGROUND:Radical cystectomy for bladder cancer is associated with a high risk of needing red blood cell transfusion. Tranexamic acid reduces blood loss during cardiac and orthopedic surgery, but no study has yet evaluated tranexamic acid use during cystectomy. METHODS:A randomized, double-blind (surgeon-, anesthesio...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2626-3
更新日期:2018-05-02 00:00:00
abstract:BACKGROUND:The key aim of the study is to establish an agreed standardised core outcome set (COS) for use when evaluating non-pharmacological health and social care interventions for people living at home with dementia. METHODS/DESIGN:Drawing on the guidance and approaches of the Core Outcome Measures in Effectiveness...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2584-9
更新日期:2018-04-24 00:00:00
abstract:BACKGROUND:Osteoarthritis (OA) is the most prevalent chronic joint disease, characterized by joint structural deterioration, pain and loss of function among the elders. It is also associated with several extra-articular symptoms (fatigue, sleep disorders, anxiety and depression) and a reduction of life quality. Studies...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2625-4
更新日期:2018-04-17 00:00:00